Multiple dose design Sample size [Power / Sample Size]

posted by Researcher101 – Egypt, 2020-10-14 10:21 (17 d 13:48 ago) – Posting: # 21997
Views: 368

Dears, I just wanna know if Steadystate Cmax intrasubject variability will be considered in sample size calculations of multiple dose BE? or just Cmax of single dose?

Also is it in the safe side to estimate sample size based on Cmax single dose not multiple dose?


Edit: Category changed; see also this post #1[Helmut]

Complete thread:

Activity
 Admin contact
21,180 posts in 4,415 threads, 1,476 registered users;
online 5 (0 registered, 5 guests [including 5 identified bots]).
Forum time: Saturday 23:09 CET (Europe/Vienna)

To know that we know what we know,
and to know that we do not know what we do not know,
that is true knowledge.    Nicolaus Copernicus

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5