Ratio calculation of fully replicate study [RSABE / ABEL]
Hi Mithu,
» » Without knowing your SAS code it would be reading tea leaves.
»
» We have used Progesterone program.
… which nowhere gives the subject’s T/R-ratios.
» » $$x/y=\exp (\log_{e}x-\log_{e}y)\;\left\{x,y \in \mathbb{R}^{+} \right\}\; {\color{red}{\neq}}\log_{e}x/\log_{e}y$$
» Still I could not understand.
Calculating the ratio of logs (2. of your OP) is nonsense.
The individual averaged log-differences \(I_{ij}\) (for subject \(i\) in sequence \(j\)) are computed in the FDA’s SAS macro by
Let’s have a look at the EMA’s full replicate reference data set:
Which leaves my second question open:
» » Why on earth do you want to use Excel?
» » Without knowing your SAS code it would be reading tea leaves.
»
» We have used Progesterone program.
… which nowhere gives the subject’s T/R-ratios.
» » $$x/y=\exp (\log_{e}x-\log_{e}y)\;\left\{x,y \in \mathbb{R}^{+} \right\}\; {\color{red}{\neq}}\log_{e}x/\log_{e}y$$
» Still I could not understand.
Calculating the ratio of logs (2. of your OP) is nonsense.
The individual averaged log-differences \(I_{ij}\) (for subject \(i\) in sequence \(j\)) are computed in the FDA’s SAS macro by
ilat=0.5*(lat1t+lat2t-lat1r-lat2r);
Let’s have a look at the EMA’s full replicate reference data set:
SUBJECT DATA FORMULATION PERIOD SEQUENCE logDATA
1 2285.96 R 1 BABA 7.734541
1 1955.82 T 2 BABA 7.578565
1 1345.94 R 3 BABA 7.204848
1 2856.24 T 4 BABA 7.957261

Which leaves my second question open:
» » Why on earth do you want to use Excel?
—
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Helmut Schütz
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Dif-tor heh smusma 🖖
Helmut Schütz
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The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- Ratio calculation of fully replicate study Mithu 2020-07-09 09:18 [RSABE / ABEL]
- Ratio calculation of fully replicate study Helmut 2020-07-09 10:51
- Ratio calculation of fully replicate study Mithu 2020-07-09 11:23
- Ratio calculation of fully replicate study Helmut 2020-07-09 10:51