MRT and Gravity duration [NCA / SHAM]

posted by mittyri – Russia, 2020-06-14 22:24 (173 d 03:10 ago) – Posting: # 21539
Views: 2,752

Dear Astea,

» MRT is a most common PK parameters that compels to look at the AUMC. There existed approaches4 to use MRT instead of T1/2 in order to choose the appropriate washout period.

Just my 2 cents regarding MRT. You cannot estimate it for non-IV ways of administration. For non-IV that parameter is called 'gravity duration', since includes both MIT and MRT. See here for discussion.

Kind regards,
Mittyri

Complete thread:

Activity
 Admin contact
21,240 posts in 4,431 threads, 1,482 registered users;
online 6 (1 registered, 5 guests [including 3 identified bots]).
Forum time: Saturday 00:35 CET (Europe/Vienna)

I believe there is no philosophical high-road in science,
with epistemological signposts. No, we are in a jungle
and find our way by trial and error,
building our road behind us as we proceed.    Max Born

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5