MRT and Gravity duration [NCA / SHAM]

posted by mittyri – Russia, 2020-06-14 22:24 (98 d 19:51 ago) – Posting: # 21539
Views: 2,562

Dear Astea,

» MRT is a most common PK parameters that compels to look at the AUMC. There existed approaches4 to use MRT instead of T1/2 in order to choose the appropriate washout period.

Just my 2 cents regarding MRT. You cannot estimate it for non-IV ways of administration. For non-IV that parameter is called 'gravity duration', since includes both MIT and MRT. See here for discussion.

Kind regards,
Mittyri

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