volume of distribution at steady state [PK / PD]

posted by martin  – Austria, 2011-10-18 07:49 (3537 d 16:11 ago) – Posting: # 7510
Views: 16,702

Dear all!

I have a questions regarding calculation of volume of distribution at steady state (Vss). After IV bolus administration Vss can be calculated based on the non-compartmental theory as doseiv x AUMC0-infinity / AUC20-infinity. Now let us assume that the concentrations over time after extra vascular administration can be adequately described by a one-compartmental model with first order absorption and first order elimination.

How can the volume of distribution at steady state be calculated under this model? Can the above formula be adjusted straightforwardly using the bioavailability F to calculate Vss = (dosepo x F x AUMC0-infinity) / AUC20-infinity?

best regards


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