Bracketing Approach [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-06-12 12:12 (107 d 10:43 ago) – Posting: # 21531
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Dear all,

two participants of the recent survey commented that the “Bracketing Approach” (e.g., non-superiority of Cmax, non-inferiority of Cmin)* and testing for equivalence of AUC is not available in the software they are using most (without naming it).

In PowerTOST it is implemented (see its vignette for examples). Since the CV of AUC is generally lower than the ones of Cmax/Cmin it will not drive the sample size.



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