More about the tables [Power / Sample Size]

posted by Helmut Homepage – Vienna, Austria, 2020-05-29 13:30 (115 d 03:45 ago) – Posting: # 21490
Views: 856

Dear sample size geeks, nerds, and simul-ants (weirdos for short),

for each combination of design, power, GMR, and CV: Red circles = sample sizes of the Two Lászlós (if >201 none). Green bars = sampleN.scABEL(..., nsims = 1e5) or sampleN.RSABE(..., nsims = 1e5); always balanced sequences. Blue circles = twenty runs simulated with 10,000 sim’s each (random seeds). Starting from the respective result, I decreased the sample size whilst maintaining power. This might give unbalanced sample sizes (even sample sizes for the partial replicate and odd ones for the full replicate).

ABEL (EMA)

Now a comparison of the reported sample sizes (y-axis) vs. PowerTOST’ (x-axis). Blue from the tables, and red up-rounded to the next complete sequence. Do the linear fits closer to the unity line? Sometimes yes, sometimes not.

RSABE (FDA)

Comparison of the reported sample sizes (y-axis) vs. PowerTOST’ (x-axis). Blue from the tables, and red up-rounded to the next complete sequence. Do the linear fits get closer to the unity line? Generally yes.

The upper part of the RSABE sample sizes looks disturbing first. Explanation: Since the sample sizes are generally smaller than for ABEL, the many imbalanced sequences have a larger impact. However, rounding up to the next complete sequence (red circles) in the lower part gives a better match (closer to the unity line).

Maybe you can make sumfink out of it. I still hold that 10,000 simulations are too few.

Dif-tor heh smusma 🖖
Helmut Schütz
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