crap [Two-Stage / GS Designs]

posted by d_labes  – Berlin, Germany, 2020-02-16 19:34 (221 d 21:18 ago) – Posting: # 21175
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Dear Helmut,

» ...
»         Name Method Type  GMR power  alpha     TIE  ANVISA   comp delta
»          SLF      B    1 0.90   0.8 0.0272 0.04997 0.04999 higher  2E-5
»          SLF      B    1 0.90   0.9 0.0268 0.04985 0.04977  lower  8E-5
»       Potvin      B    1 0.95   0.8 0.0294 0.04876 0.04879 higher  3E-5
»   Potvin-SLF      B    1 0.95   0.8 0.0302 0.04999 0.05020 higher  2E-4
»     Fuglsang      B    1 0.95   0.9 0.0284 0.04960 0.04958  lower  2E-5
» Fuglsang-SLF      B    1 0.95   0.9 0.0286 0.04999 0.05032 higher  3E-4
»     Montague      D    2 0.90   0.8 0.0280 0.05180 0.05181 higher  1E-5
» Montague-SLF      D    2 0.90   0.8 0.0268 0.04998 0.04980  lower  2E-4
»     Fuglsang    C/D    2 0.90   0.9 0.0269 0.05021 0.05011  lower  1E-4
» Fuglsang-SLF    C/D    2 0.90   0.9 0.0266 0.04995 0.04967  lower  3E-4
»       Potvin      C    2 0.95   0.8 0.0294 0.05143 0.05136  lower  7E-5
»   Potvin-SLF      C    2 0.95   0.8 0.0282 0.05010 0.05010  equal
»     Fuglsang    C/D    2 0.95   0.9 0.0274 0.05010 0.05010  equal
» Fuglsang-SLF    C/D    2 0.95   0.9 0.0275 0.04962 0.04985 higher  2E-4
»
» TIE which is significantly >0.05 in red (limit of the binomial test 0.05036). I don’t understand why in some scenarios the TIE is lower with a minimum n2.
» Counterintuitive. :confused:

I'm quite sure: This is because of the simulation error. The differences of the TIE without and with min.n2 are so small. See the last column above.
Any try with a different seed of the random number generator may and will change the comparison.


Edit: Removed irrelevant columns for clarity. [Helmut]

Regards,

Detlew

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