Kenward-Roger? [RSABE / ABEL]

posted by PharmCat  – Russia, 2019-11-06 14:43 (528 d 10:22 ago) – Posting: # 20755
Views: 5,655

» From a theoretical perspective, maybe. The Kenward-Roger approximation recovers more information from the data, higher degrees of freedom and hence, results in a narrower confidence interval than with Satterthwaite’s degrees of freedom. Since the latter is explicitely recommended in the progesterone guidance I have some doubts whether the FDA would accept that.

I thought that Kenward-Roger provide the same DF as Satterthwaite's for one-dimension effects, so as CI for coefficient is one-dimension hypothesis DF should be the same, as it describes in reference paper, may be SAS make any corrections, I don't know... Is any comparations anywhere?

Complete thread:

 Admin contact
21,419 posts in 4,475 threads, 1,511 registered users;
online 16 (0 registered, 16 guests [including 2 identified bots]).
Forum time: Sunday 02:05 CEST (Europe/Vienna)

Nothing fails like success because you do not learn anything from it.
The only thing we ever learn from is failure.
Success only confirms our superstitions.    Kenneth E. Boulding

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz