Kenward-Roger? [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2019-11-06 12:49 (963 d 02:01 ago) – Posting: # 20754
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Hi Mahmoud,

» if you need to take into account the missing data use proc mixed in SAS with dffm=Kr

From a theoretical perspective, maybe. The Kenward-Roger approximation recovers more information from the data, higher degrees of freedom and hence, results in a narrower confidence interval than with Satterthwaite’s degrees of freedom. Since the latter is explicitly recommended in the progesterone guidance I have some doubts whether the FDA would accept that.

» otherwise use proc glm in SAS, this procedure do not take into account the missing data

Sure.

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