apple tree for two-stage [Two-Stage / GS Designs]

posted by Astea – Russia, 2019-09-16 20:39  – Posting: # 20602
Views: 1,107

Dear Elena777!

» tree?

I meant decision scheme (in graph theory mathematicians call "trees" undirected graphs). See also this message.

» To be in compliance with method C of Potvin, we re-calculate CI for Cmax with α=0,0294. Let`s assume that BE criterion for Cmax is met after this step. Should we also re-calculate CI for AUC with α=0,0294? Otherwise, finally we will have the following in a CSR: BE criterion was met for AUC using α=0,05 (90%CI) and BE criterion was met for Cmax using α=0,0294 (94,12% CI). Does it look OK?

In this situation we still have to go to the next stage. As it was shown before the fail for AUC (if it has less variability than Cmax) in the second stage is very unlikely. So it just doesn't matter what was CI for AUC after the first stage, the second stage for Cmax should be crucial.

"We are such stuff as dreams are made on, and our little life, is rounded with a sleep"

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