## Geometric mean and CV [Power / Sample Size]

Thanks. But what I Do not understand is, is it even reasonable to use the geometric CV for the reference? Isn’t the CV you want to input into a sample calculation the CV corresponding to the difference of the Test and Reference? Since you do not have the Test group here, I am a bit confused as to what using the geometric CV of only the reference tells you. In your slides, you have a lone that says “if you have only mean and sd of the reference, a pilot study is unavoidable.”

What am I missing?

Thanks.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

What am I missing?

Thanks.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

### Complete thread:

- Input for CV when small first-in-man has been run Rocco_M 2019-09-03 18:45 [Power / Sample Size]
- Geometric mean and CV Helmut 2019-09-05 14:05
- Geometric mean and CVRocco_M 2019-09-05 23:49
- Geometric mean and CV Helmut 2019-09-06 00:15
- Geometric mean and CV Rocco_M 2019-09-06 17:49
- Geometric mean and CV Helmut 2019-09-06 18:15
- Geometric mean and CV ElMaestro 2019-09-06 19:03
- Geometric mean and CV Helmut 2019-09-07 09:57
- Geometric mean and CV Rocco_M 2019-09-09 13:31
- Assumptions… Helmut 2019-09-09 14:09
- Assumptions… Rocco_M 2019-09-09 16:35
- Assumptions… Helmut 2019-09-09 17:19
- Assumptions… Rocco_M 2019-09-13 21:28
- t-test & Welch-test Helmut 2019-09-14 00:16
- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02
- assumptions vs. realizations Helmut 2019-09-18 11:04

- sampleN.TOST and CI.BE Rocco_M 2019-09-17 22:02

- t-test & Welch-test Helmut 2019-09-14 00:16

- Assumptions… Rocco_M 2019-09-13 21:28

- Assumptions… Helmut 2019-09-09 17:19

- Assumptions… Rocco_M 2019-09-09 16:35

- Assumptions… Helmut 2019-09-09 14:09

- Geometric mean and CV Rocco_M 2019-09-09 13:31

- Geometric mean and CV Helmut 2019-09-07 09:57

- Geometric mean and CV ElMaestro 2019-09-06 19:03

- Geometric mean and CV Helmut 2019-09-06 18:15

- Geometric mean and CV Rocco_M 2019-09-06 17:49

- Geometric mean and CV Helmut 2019-09-06 00:15

- Geometric mean and CVRocco_M 2019-09-05 23:49

- Geometric mean and CV Helmut 2019-09-05 14:05