Power of Proc Power [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2019-03-20 18:37  – Posting: # 20058
Views: 1,952

(edited by d_labes on 2019-03-20 19:15)

Dear sury,

Additionally to what Helmut has said:

» we have not yet finalized the SOP, and moreover we use the SAS Software procedure "PROC POWER" for the estimation of the sample size. But however we wanted it to be more accurate sample size for that we want to include the deletti tables.

PROC POWER doesn't allow a power calculation or a sample size estimation out of the box for study designs used mainly in bioequivalence studies, beside other f.i. for the standard 2x2 crossover design! Except if you assume no period effects present. See here.
But this assumption isn't appropriate in many cases.

You have to roll your own piece of software. See f.i. this paper.
And if you do so: You have to validate.

Regards,

Detlew

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