Group Effect in Full Replicate Design [RSABE / ABEL]

posted by Helmut Homepage – Vienna, Austria, 2018-09-12 17:09 (2483 d 14:07 ago) – Posting: # 19276
Views: 8,173

Hi Gm,

❝ We don't want to take any decisions on the basis of model terms.


Very good.

❝ Our thought is, we need to check group effect for both ABE and RSABE also.


Again: you have to include “group” as a factor in various ways (see below).

❝ If this correct, how the model is to be designed for RSABE?


As I wrote above

❝ ❝ Honestly, I have no clue how to modify the models given in the progesterone-guidance.


Specifically the scaling-part…
For the ABE part (if swR <0.294) like the FDA’s Model II:

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
23,425 posts in 4,928 threads, 1,681 registered users;
80 visitors (0 registered, 80 guests [including 13 identified bots]).
Forum time: 07:17 CEST (Europe/Vienna)

Fools with Tools Are Still Fools!    Anonymous

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5