Lower bound for power of two combined TOST? [Power / Sample Size]

posted by ElMaestro  – Denmark, 2018-07-25 12:07 (1474 d 14:39 ago) – Posting: # 19097
Views: 4,599

Hi d_labes,

»

Power >= PAUC + PCmax - (2 - 1)

where PAUC is the estimate of power for AUC and PCmax is the estimate of power for Cmax.

Surely that's either wrong or an approximation that has some validity within a set of strict conditions. I have not read that work or reference 918, but it looks outright wrong.
With that equation power could become negative, go figure.

By the way, the term pooled in the first sentence is also weird. The variances estimates for Cmax and AUCt are not "pooled", but I think they meant that the pool is just the dichotomous set of two variances.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
22,288 posts in 4,665 threads, 1,583 registered users;
online 4 (0 registered, 4 guests [including 2 identified bots]).
Forum time: Monday 02:46 CEST (Europe/Vienna)

Don’t compromise yourself.
You are all you’ve got.    Janis Joplin

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5