Lower bound for power of two combined TOST? [Power / Sample Size]

posted by ElMaestro  – Denmark, 2018-07-25 12:07 (911 d 19:45 ago) – Posting: # 19097
Views: 3,887

Hi d_labes,

»

Power >= PAUC + PCmax - (2 - 1)

where PAUC is the estimate of power for AUC and PCmax is the estimate of power for Cmax.

Surely that's either wrong or an approximation that has some validity within a set of strict conditions. I have not read that work or reference 918, but it looks outright wrong.
With that equation power could become negative, go figure.

By the way, the term pooled in the first sentence is also weird. The variances estimates for Cmax and AUCt are not "pooled", but I think they meant that the pool is just the dichotomous set of two variances.

Pass or fail!
ElMaestro

Complete thread:

Activity
 Admin contact
21,310 posts in 4,445 threads, 1,489 registered users;
online 7 (0 registered, 7 guests [including 4 identified bots]).
Forum time: Friday 06:53 CET (Europe/Vienna)

Statistics is, or should be, about scientific investigation
and how to do it better, but many statisticians believe
it is a branch of mathematics.    George E.P. Box

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5