Power decrease for the highly correlation of AUCt and AUCinf [Power / Sample Size]

posted by libaiyi – China, 2018-05-23 10:40 (2218 d 05:38 ago) – Posting: # 18801
Views: 5,254

Hi, all

I want to ask about power calculation. In BE, Cmax, AUCt, and AUCinf are all needed for power consideration. And the power for each one need to be bigger than overall power for the accumulation of power. But AUCinf and AUCt are highly correlated, so could I decrease the individual power and only consider about AUCt and Cmax for the power setting?

Thanks in advance.

Complete thread:

UA Flag
Activity
 Admin contact
23,057 posts in 4,840 threads, 1,641 registered users;
57 visitors (0 registered, 57 guests [including 7 identified bots]).
Forum time: 16:19 CEST (Europe/Vienna)

You should treat as many patients as possible with the new drugs
while they still have the power to heal.    Armand Trousseau

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5