Lag time in WinNonlin - bug or feature? [Software]

posted by Helmut Homepage – Vienna, Austria, 2008-05-26 15:26 (4535 d 06:11 ago) – Posting: # 1872
Views: 8,912

Dear all,

I just discovered another nice one.

Quoting WinNonlin’s 5.2 online help (Noncompartmental analysis > Plasma or serum data > Table B-3.):
Tlag    Extravascular input (model 200) only. Tlag is the time prior
        to the first measur­able (non-zero) concentration.

Beware that non-zero concentration must be taken literally for all other values, i.e., if you have values prior to the first measurable coded as ‘Missing’ or ‘BQL’ or any other non-numeric value, WinNonlin will come up with a Tlag of zero!
Example:
+-------+---------+-------+-------+
| time  | code 1  | code 2| =zero |
+-------+---------+-------+-------+
|  0.00 | MissingBQL  |  0    |
|  0.25 | MissingBQL  |  0    |
|  0.50 | MissingBQL  |  0    |
|  0.75 | MissingBQL  |  0    |
|  1.00 | MissingBQL  |  0    |
|  1.5  |  10.5   | 10.5  | 10.5  |
|  2.0  |  15.9   | 15.9  | 15.9  |
|  2.5  |  18.4   | 18.4  | 18.4  |
|  3.0  |  19.4   | 19.4  | 19.4  |
|  4    |  19.4   | 19.4  | 19.4  |
|  6    |  17.0   | 17.0  | 17.0  |
|  9    |  13.4   | 13.4  | 13.4  |
| 12    |  10.6   | 10.6  | 10.6  |
| 16    |   7.68  |  7.68 |  7.68 |
| 24    |   4.05  |  4.05 |  4.05 |
| 36    |   1.55  |  1.55 |  1.55 |
+-------+---------+-------+-------+
| Tlag  |   0     |  0    |  1.5  |
(see Edit below)
+-------+---------+-------+-------+

If you want to get correct results you must recode your values first (Tools > Status Codes)!


Edit: See this post. WinNonlin's result for the third column is 1.0 (in agreement with the manual).

Dif-tor heh smusma 🖖
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

Activity
 Admin contact
21,179 posts in 4,414 threads, 1,474 registered users;
online 6 (0 registered, 6 guests [including 4 identified bots]).
Forum time: Sunday 20:38 CET (Europe/Vienna)

Mediocrity knows nothing higher than itself,
but talent instantly recognizes genius.    Arthur Conan Doyle

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5