Lag time in WinNonlin - bug or feature? [Software]

posted by Helmut Homepage – Vienna, Austria, 2008-05-26 17:26 (5806 d 17:57 ago) – Posting: # 1872
Views: 11,075

Dear all,

I just discovered another nice one.

Quoting WinNonlin’s 5.2 online help (Noncompartmental analysis > Plasma or serum data > Table B-3.):
Tlag    Extravascular input (model 200) only. Tlag is the time prior
        to the first measur­able (non-zero) concentration.

Beware that non-zero concentration must be taken literally for all other values, i.e., if you have values prior to the first measurable coded as ‘Missing’ or ‘BQL’ or any other non-numeric value, WinNonlin will come up with a Tlag of zero!
Example:
+-------+---------+-------+-------+
| time  | code 1  | code 2| =zero |
+-------+---------+-------+-------+
|  0.00 | MissingBQL  |  0    |
|  0.25 | MissingBQL  |  0    |
|  0.50 | MissingBQL  |  0    |
|  0.75 | MissingBQL  |  0    |
|  1.00 | MissingBQL  |  0    |
|  1.5  |  10.5   | 10.5  | 10.5  |
|  2.0  |  15.9   | 15.9  | 15.9  |
|  2.5  |  18.4   | 18.4  | 18.4  |
|  3.0  |  19.4   | 19.4  | 19.4  |
|  4    |  19.4   | 19.4  | 19.4  |
|  6    |  17.0   | 17.0  | 17.0  |
|  9    |  13.4   | 13.4  | 13.4  |
| 12    |  10.6   | 10.6  | 10.6  |
| 16    |   7.68  |  7.68 |  7.68 |
| 24    |   4.05  |  4.05 |  4.05 |
| 36    |   1.55  |  1.55 |  1.55 |
+-------+---------+-------+-------+
| Tlag  |   0     |  0    |  1.5  |
(see Edit below)
+-------+---------+-------+-------+

If you want to get correct results you must recode your values first (Tools > Status Codes)!


Edit: See this post. WinNonlin's result for the third column is 1.0 (in agreement with the manual).

Dif-tor heh smusma 🖖🏼 Довге життя Україна! [image]
Helmut Schütz
[image]

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

UA Flag
Activity
 Admin contact
22,987 posts in 4,824 threads, 1,663 registered users;
78 visitors (0 registered, 78 guests [including 7 identified bots]).
Forum time: 11:24 CEST (Europe/Vienna)

The only way to comprehend what mathematicians mean by Infinity
is to contemplate the extent of human stupidity.    Voltaire

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5