Bioequivalence and Bioavailability Forum

❝ I'm also a little confused about the results that Helmut quoted above.

❝ Running that same data in 5.2.1 I get the result of 1 for Tlag in the third group which agrees with the definition in the help file. I don't recall this function being changed for some versions in WNL so is there a typo in your table […]

❝ […] so compartmental modelling is probably going to be more useful if you need to define this more 'precisely'.

• PK modeling is not acceptable in the field of BE from a regulatory point of view.
  
• In real life datasets absorption regularily is difficult to model. Quite often k₀₁ is very inprecise; you have to play around with constraints (WinNonlin’s terminology: bounds) to get a ‘resonable’ value of t_lag…

❝ I concur it would be useful for WNL to 'intrinsically' recognise BLQs […]

❝ […] the appropriate process is currently to recode non-numeric values first using (Tools > Status Codes).