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Hi helmut,
»
» » As I simulate 3 condition of infusion by WinNonlin PK Modeling,
» » 1. infusion by constant rate for 30min and complete the infusion at 30min;
» » 2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;
» » 3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.
» » below is what i get:
» » [image]
» »
» » It's different from (what you have present)your result about Cmax. Now I am confused, I don't know why.
»
» Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin.
What I said it's different meanss the Cmax is different in the 3 condition, but not the same as your result.
» Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?
Yes, AUC is the same,I mean Cmax is different.
»
» » As I simulate 3 condition of infusion by WinNonlin PK Modeling,
» » 1. infusion by constant rate for 30min and complete the infusion at 30min;
» » 2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;
» » 3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.
» » below is what i get:
» » [
» »
» » It's different from (what you have present)your result about Cmax. Now I am confused, I don't know why.
»
» Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin.
What I said it's different meanss the Cmax is different in the 3 condition, but not the same as your result.
» Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?
Yes, AUC is the same,I mean Cmax is different.
Complete thread:
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-06 10:48
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Different PK profile Helmut 2018-02-06 13:28
- Different PK profile ssussu 2018-02-07 02:50
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profile ssussu 2018-02-07 11:42
- Suitable equipment? Helmut 2018-02-07 14:13
- Suitable equipment? ssussu 2018-02-08 04:07
- AUC=f·D/CL Helmut 2018-02-08 10:28
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CL Helmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-09 00:31
- AUC=f·D/CL Helmut 2018-02-08 21:55
- AUC=f·D/CL ssussu 2018-02-08 11:21
- AUC=f·D/CL Helmut 2018-02-08 10:28
- Suitable equipment? ssussu 2018-02-08 04:07
- Suitable equipment? Helmut 2018-02-07 14:13
- Different PK profile ssussu 2018-02-07 11:42
- Different PK profile Helmut 2018-02-07 11:04
- Different PK profile ssussu 2018-02-07 02:50
- When the the infusion speed deviate from the protocol specified ElMaestro 2018-02-07 13:20
- When the the infusion speed deviate from the protocol specified ssussu 2018-02-08 04:23
- Different PK profile Helmut 2018-02-06 13:28
Ing. Helmut Schütz