AUC=f·D/CL [Study As­sess­ment]

posted by ssussu – China, 2018-02-09 01:31 (2704 d 12:59 ago) – Posting: # 18384
Views: 10,630

Hi helmut,

❝

❝ ❝ As I simulate 3 condition of infusion by WinNonlin PK Modeling,

❝ ❝ 1. infusion by constant rate for 30min and complete the infusion at 30min;

❝ ❝ 2. infusion 15min and stop for 5min and speed up the infusion rate to complete at 30min;

❝ ❝ 3. infusion 15min and stop for 5min and keep the same infusion rate and complete at 35min.

❝ ❝ below is what i get:

❝ ❝ [image]

❝ ❝

❝ ❝ It's different from (what you have present)your result about Cmax. Now I am confused, I don't know why.:confused:

❝

❝ Of course it looks different. You have an enlarged time scale (one hour instead of my two) and a much faster elimination. My t½ was eight hours (k 0.0866434). Sorry to say but you should try to understand the basic concepts of PK before using such a powerful tool like Phoenix/WinNonlin. :no:

What I said it's different meanss the Cmax is different in the 3 condition, but not the same as your result.

❝ Last hint: Run NCA (lin-up/log-down trapezoidal) on the predicted data, extrapolate to infinity, and compare AUCinf of the three scenarios. What do you get?

Yes, AUC is the same,I mean Cmax is different.

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