Different PK profile [Study As­sess­ment]

posted by ssussu – China, 2018-02-07 10:42  – Posting: # 18369
Views: 5,817

Hi Helmut,

» » The dose is not lost because the nurse expel the burble by squeezing the tube to float the burble up from the liquid surface of the tube.
»
» I don’t understand. Did you use an infusion pump or an infusion bottle / drip chamber?

Yes, the burble is extruded by squeezing the tube to float the burble up from the liquid surface of the tube, like this
[image]
so, the dose is not lost.

» » » 2. only if you lost nothing […] the Cmax and AUC will equal the one with a constant rate infusion.
» »
» » […] if the dose is not lost, can i say just the AUC will be effect but the Cmax is the same with the canstant rate infusion?
»
» Read again what I wrote above.

So, you mean the Cmax and the AUC both will equal the one with a constant rate infusion? Don't we need to consider the eliminate rate? if we speed up the infusion rate while the eliminate rate is not change, the Cmax won't be greater than the constant rate infusion?


Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

Complete thread:

Activity
 Mix view
Bioequivalence and Bioavailability Forum |  Admin contact
19,607 posts in 4,159 threads, 1,340 registered users;
online 7 (0 registered, 7 guests [including 6 identified bots]).
Forum time (Europe/Vienna): 03:57 UTC

Every sentence I utter must be understood
not as an affirmation
but as a question.    Niels Bohr

The BIOEQUIVALENCE / BIOAVAILABILITY FORUM is hosted by
BEBAC Ing. Helmut Schütz
HTML5