Suitable equipment? [Study As­sess­ment]

posted by ssussu – China, 2018-02-08 03:07  – Posting: # 18377
Views: 6,367

Hi Helmut,

Thank you for your patience.

» » So, you mean the Cmax and the AUC both will equal the one with a constant rate infusion?
» Yes!

I thought the AUC would be effect because I saw the the black area in the below picture. Now i know the AUC is only depend on the dose as you said.

» For the next time I strongly recommend infusion pumps (yeah, I know, expensive): Exact infusion rates, no bubbles, no problems.

Yes, they used the infusion pumps, and I don't know why it occurs bubbles and I need to do more detailed investigation.

» If you would have kept the original infusion rate (after the five minutes stop), i.e., complete it at 35 minutes, you would have seen a Cmax which is 0.35% (!) lower than expected with the planned schedule – if you have an early sampling time point. If not, you will observed a lower Cmax. How much lower depends on the sampling schedule and the elimination rate. Theoretically the AUC is not affected (depends only on the dose).

Could I say (theoretically) that no matter how long will I stop the infusion,only if I complete infusion at 0.5h,the Cmax will be same with constant rate infusion for 0.5h?

» Why did it take the nurse five minutes to expel the bubble? In my experience about one minute should be sufficient.

Yes, actually they take 2min and I exaggerate it to 5min, want to see the effect if the stop time is not short enough to be ignore.

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! [Helmut]

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