Bioequivalence and Bioavailability Forum • TIE for NTIDs

TIE for NTIDs [Power / Sample Size]

posted by Helmut – Vienna, Austria, 2018-02-06 13:34 (2598 d 09:42 ago) – Posting: # 18363
Views: 21,559

Dear Detlew,

❝ […] the entry suggest for me that the TIE (with values >0.05) is significant <0.05. Maybe it's my misunderstanding. To avoid this many statisticians state "significant at alpha=0.05". But then the Hypotheses have to be given else.

I see!

Change lines 17 and 32 from

res  <- cbind(CVs, n=NA, forced=FALSE, GMR=NA, TIE=NA,

              signif=" n. s.", stringsAsFactors=FALSE)

  if (res[j, "TIE"] > bt.sig) res[j, "signif"] <- "p<0.05"

res  <- cbind(CVs, n=NA, forced=FALSE, GMR=NA, TIE=NA,

              "signif >0.05"="n. s.", stringsAsFactors=FALSE)

  if (res[j, "TIE"] > bt.sig)

    res[j, "signif >0.05"] <- "at alpha=0.05"

Will give

swT/swR: 2 

   CVwT   CVwR   n      GMR      TIE  signif >0.05

 0.0600 0.0300 430 1.032106 0.050580 at alpha=0.05

 0.0801 0.0400 156 1.043027 0.048675         n. s.

 ...

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Helmut Schütz

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Complete thread:

Sample size for 4-period 4-sequence crossover BE study Bryony Simmons 2018-02-01 12:16 [Power / Sample Size]
- function sampleN.TOST of package PowerTOST Helmut 2018-02-01 13:01
  - Alpha adjustment in higher order crossover d_labes 2018-02-01 14:01
    - Deficiencies Helmut 2018-02-01 15:48
      - Deficiencies nobody 2018-02-01 17:10
      - Deficiencies d_labes 2018-02-01 18:57
        
        Deficiencies Relaxation 2018-02-02 11:12
        
        Deficiencies nobody 2018-02-02 12:49
        Deficiencies Helmut 2018-02-02 16:14
        
        Deficiencies Relaxation 2018-02-02 19:41
        
        alpha... where is omega? Astea 2018-02-02 21:45
        
        α and no ω Helmut 2018-02-02 23:39
        
        TIE for NTIDs d_labes 2018-02-04 12:40
        
        TIE for NTIDs Astea 2018-02-04 20:04
        
        TIE for NTIDs Helmut 2018-02-05 01:01
        
        TIE for NTIDs d_labes 2018-02-05 16:40
        
        TIE for NTIDs Helmut 2018-02-05 17:49
        
        TIE for NTIDs d_labes 2018-02-05 22:17
        
        TIE for NTIDsHelmut 2018-02-06 12:34
        
        TIE for NTIDs d_labes 2018-02-05 16:35
        
        bow TIE for NTIDs Astea 2018-02-05 17:52
        
        bow TIE for NTIDs Helmut 2018-02-05 18:10
        
        111.11 for NTIDs Astea 2018-02-05 19:27
        
        111.11 for NTIDs Helmut 2018-02-06 00:12
        
        bow TIE for NTIDs d_labes 2018-02-05 22:33