Bioequivalence and Bioavailability Forum • TIE for NTIDs

TIE for NTIDs [Power / Sample Size]

posted by d_labes – Berlin, Germany, 2018-02-05 23:17 (2533 d 02:15 ago) – Posting: # 18359
Views: 21,045

Dear Helmut,

❝ ❝ Only one nitpicking:

❝ ❝

❝ ❝ I think the entries under signif

❝ ❝ p<0.05 should read p>0.05.

❝

❝ Hhm, why? I’m testing at the 5% level for a significant inflation. The limit for 10⁶ sim’s is

❝ binom.test(0.05*1e6, 1e6, alternative="less")$conf.int[2]

❝ [1] 0.05035995

❝ Hence, any TIE > this value should be significant.

That's totally correct. But the entry suggest for me that the TIE (with values >0.05) is significant <0.05. Maybe it's my misunderstanding. To avoid this many statisticians state "significant at alpha=0.05". But then the Hypotheses have to be given else.

—
Regards,

Detlew

Complete thread:

Sample size for 4-period 4-sequence crossover BE study Bryony Simmons 2018-02-01 12:16 [Power / Sample Size]
- function sampleN.TOST of package PowerTOST Helmut 2018-02-01 13:01
  - Alpha adjustment in higher order crossover d_labes 2018-02-01 14:01
    - Deficiencies Helmut 2018-02-01 15:48
      - Deficiencies nobody 2018-02-01 17:10
      - Deficiencies d_labes 2018-02-01 18:57
        
        Deficiencies Relaxation 2018-02-02 11:12
        
        Deficiencies nobody 2018-02-02 12:49
        Deficiencies Helmut 2018-02-02 16:14
        
        Deficiencies Relaxation 2018-02-02 19:41
        
        alpha... where is omega? Astea 2018-02-02 21:45
        
        α and no ω Helmut 2018-02-02 23:39
        
        TIE for NTIDs d_labes 2018-02-04 12:40
        
        TIE for NTIDs Astea 2018-02-04 20:04
        
        TIE for NTIDs Helmut 2018-02-05 01:01
        
        TIE for NTIDs d_labes 2018-02-05 16:40
        
        TIE for NTIDs Helmut 2018-02-05 17:49
        
        TIE for NTIDsd_labes 2018-02-05 22:17
        
        TIE for NTIDs Helmut 2018-02-06 12:34
        
        TIE for NTIDs d_labes 2018-02-05 16:35
        
        bow TIE for NTIDs Astea 2018-02-05 17:52
        
        bow TIE for NTIDs Helmut 2018-02-05 18:10
        
        111.11 for NTIDs Astea 2018-02-05 19:27
        
        111.11 for NTIDs Helmut 2018-02-06 00:12
        
        bow TIE for NTIDs d_labes 2018-02-05 22:33