CV from CI [Power / Sample Size]

posted by Louis52 – 2018-02-04 15:38 (2708 d 17:17 ago) – Posting: # 18341
Views: 7,273

Hi Helmut,
Thank you for the explanation :-)
Probably, most of the times we would actually know the PE from a previous study together with the CI. That's why I would not see the need the recalculate the PE (as the GMR for either AUCs or Cmaxs). But I completely agree that if we get from a published article only the information about the GMR limits for AUC or Cmax, then this is a very clever way of deriving the CVintra.
Couple of more questions:
  1. Presumably, n1 and n2 are form the previous study, right?
  2. Where 0.91 and 1.15 are coming from? Did you select them just as an example or there is a particular reason?
Thanks!

Complete thread:

UA Flag
Activity
 Admin contact
23,427 posts in 4,929 threads, 1,676 registered users;
44 visitors (0 registered, 44 guests [including 22 identified bots]).
Forum time: 09:56 CEST (Europe/Vienna)

Many people tend to look at programming styles and languages like religions:
if you belong to one, you cannot belong to others.
But this analogy is another fallacy.    Niklaus Wirth

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5