Bioequivalence and Bioavailability Forum • CV from CI

CV from CI [Power / Sample Size]

posted by Louis52 – 2018-02-03 18:12 (1880 d 16:02 ago) – Posting: # 18337
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I guess I'm still a bit confused. Yes, it is about what is on the slide 25 'Hints' in the last bullet point: "All you need is the 90% geometric confidence interval and the sample size." If I am to look on slide 26 when the PE is derived it seems that the CLlo and CLhi are for the ratio for AUCs or Cmaxs as Test vs Ref from previous study. So maybe this is case when there is no other information about a previous study other than that. Because otherwise if we know the MSE for AUC or Cmax then it it easy to go get directly Cvintra. Am I correct on this? Or PE is something else? I'm asking because when delta(CL) is derived it seems that we take the logs. Not sure why...
Thanks!

Complete thread:

Finding the CI limits Louis52 2018-02-01 19:57 [Power / Sample Size]
- CV from CI Helmut 2018-02-02 00:56
  - CV from CILouis52 2018-02-03 17:12
    - CV from CI Helmut 2018-02-03 21:48
      - CV from CI Louis52 2018-02-04 14:38
        
        CV from CI Helmut 2018-02-05 11:39