EMA: Method A or B [RSABE / ABEL]
❝ […] In partial replicate designs (TRR|RTR|RRT) I suggest to specify two analysis sets if data of the third period in sequence RRT is missing:
- Exclude subjects from the assessment of BE since the GL requires at least one treatment of T and R.
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- Keep subjects for the estimation of CVwR.
Yes

❝ ❝ I want a clarified answer please with guideline reference if applicable.
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❝ The Q&A document …
Thanks for the link
❝ From a purely statistical perspective my preferences are: Method C ≫ Method B > Method A. I don’t like the idea to treat subjects as a fixed effect.
That's what I believe too

Check this link: doi:10.12793/tcp.2014.22.2.78
❝ Given the observations from above, a sponsor probably would fair best with Method A only.
Of course

Edit: Full quote removed. Please delete everything from the text of the original poster which is not necessary in understanding your answer; see also this post #5! doi corrected. [Helmut]
Complete thread:
- Which is better for missing periods PROC GLM or PROC MIXED Mohamed Yehia 2018-01-23 09:48 [RSABE / ABEL]
- EMA: Method A or B Helmut 2018-01-23 11:25
- EMA: Method A or BMohamed Yehia 2018-01-23 11:56
- EMA: Method A or B Helmut 2018-01-23 11:25