Bioequivalence and Bioavailability Forum

Hi All,

Hope everything is fine and going well.

For Partial and full replicate studies, if we have some subjects with missing periods, i mean for example subjects who attended only 2 periods in partial replicate

I have only one question:

1) Which method to use following the EMA guidelines; method A "GLM" or method B "Mixed"?.

I am not an expert in statistics, however I read some papers stated "PROC GLM uses least squares or method of moments to fit general linear models. On the other hand, PROC MIXED uses Restricted (or residual) Maximum Likelihood (REML). PROC MIXED is recommended to avoid pitfalls of PROC GLM."

I want a clarified answer please with guideline reference if applicable.

Thanks.