Bioequivalence and Bioavailability Forum • Use PowerTOST

Use PowerTOST [Power / Sample Size]

posted by d_labes – Berlin, Germany, 2017-12-06 10:52 (2700 d 09:28 ago) – Posting: # 18037
Views: 15,221

Dear Astea!

❝ ...

❝ By the way, for extreme numbers from the paper by Endrényi L, Tóthfalusi L. we also get slightly underpowered study:

❝ power.scABEL(CV=0.8,n=54,theta0=0.95,design="2x3x3")

❝ [1] 0.79917

❝ power.scABEL(CV=0.8,n=72,theta0=0.9,design="2x3x3")

❝ [1] 0.79782

❝ ...

The sample sizes in the paper of the two Laszlos are based on 10 000 simulations (only).
Additionally the seed of the pseudo-random number generator for the sims was presumably different.
Try this:

power.scABEL(CV=0.8, n=54, theta0=0.95, design="2x3x3", nsims=10000)

[1] 0.7976

power.scABEL(CV=0.8, n=54, theta0=0.95, design="2x3x3", nsims=10000, setseed=F)

[1] 0.7995

power.scABEL(CV=0.8, n=54, theta0=0.95, design="2x3x3", nsims=10000, setseed=F)

[1] 0.8029

With nsims=1E6 and setseed=F on the other hand I don't succeed to obtain power>0.8 (20 tries).
One more reason to use PowerTOST's power.scABEL() / sampleN.scABEL() functions :cool:

. Also w.r.t the tables in the paper of the two Laszlos.

—
Regards,

Detlew

Complete thread:

Sample Size Estimation -Replicate design- BE limits cakhatri 2017-11-30 09:44 [Power / Sample Size]
- Reference-scaling: Don’t use FARTSSIE! Helmut 2017-11-30 10:58
  - Reference-scaling: Don’t use FARTSSIE? Astea 2017-11-30 22:50
    - Reference-scaling: Don’t use FARTSSIE! Helmut 2017-12-01 11:42
      - Reference-scaling: USE PowerTOST Astea 2017-12-01 14:16
        
        Reference-scaling: USE PowerTOST cakhatri 2017-12-04 06:00
        
        Reference-scaling: USE PowerTOST Helmut 2017-12-04 15:07
        
        Reference-scaling: USE PowerTOST cakhatri 2017-12-05 05:33
        
        Use PowerTOSTd_labes 2017-12-06 09:52
        
        Use PowerTOST, not Endrényi L, Tóthfalusi L tables mittyri 2017-12-07 16:03
        
        Precision in Endrényi L, Tóthfalusi L tables d_labes 2017-12-07 18:21
        
        Precision of PowerTOST mittyri 2017-12-08 22:56
        
        Precision of PowerTOST Helmut 2017-12-09 17:00
        
        Precision of PowerTOST mittyri 2017-12-09 21:05
        
        Precision of PowerTOST Astea 2017-12-10 00:10
        
        Precision of PowerTOST Helmut 2017-12-10 20:27
        
        Precision of PowerTOST Astea 2017-12-10 21:13
  - Reference-scaling: Don’t use FARTSSIE! pjs 2018-02-09 13:08
    - Reference-scaling: Don’t use FARTSSIE! Helmut 2018-02-09 20:15