Reference-scaling: Don’t use FARTSSIE? [Power / Sample Size]
❝ FARTSSIE cannot perform the necessary simulations and therefore, is not suitable for any of the reference-scaling methods.
Just few words in defence of FARTSSIE. May be the approximations are rude, far from exact PowerTOST (see #), but the results overally seems to be correlated for CV>30%:
design 2x2x4 2x2x3 (2x3x3 from Table)
theta0 0.9 0.9 0.9 0.95 0.95 0.95|0.9 0.9 0.9 0.95 0.95 0.95
CV,% F R T F R T F R T F R T
30 40 34 35 20 18 19 60 50 53 30 26 27
35 32 34 34 19 20 20 48 50 51 28 28 29
40 27 30 31 18 20 20 41 46 44 27 30 29
45 25 28 29 18 20 21 37 42 40 27 30 29
50 23 28 28 17 22 22 34 42 40 26 32 30
55 27 30 30 20 22 23 40 44 42 30 34 32
60 31 32 32 23 24 25 46 48 46 35 36 36
65 35 36 37 27 28 28 53 54 53 40 40 40
70 40 40 40 30 30 31 60 60 58 45 46 45
75 44 44 45 33 34 34 66 66 67 50 50 50
80 49 50 50 37 38 38 73 74 72 55 56 54
here
F - FARTSSIE22 (note: sample size should be additionally rounded)
R - PowerTOST v.1.4.6, sampleN.scABEL
T- Table from Endrényi L, Tóthfalusi L. Sample Sizes for Designing Bioequivalence Studies for Highly Variable Drugs. J Pharm Pharmaceut Sci. 2011;15(1):73–84. (*edit: the last columns refers to 2x3x3 design)
—
"Being in minority, even a minority of one, did not make you mad"
"Being in minority, even a minority of one, did not make you mad"
Complete thread:
- Sample Size Estimation -Replicate design- BE limits cakhatri 2017-11-30 09:44 [Power / Sample Size]
- Reference-scaling: Don’t use FARTSSIE! Helmut 2017-11-30 10:58
- Reference-scaling: Don’t use FARTSSIE?Astea 2017-11-30 22:50
- Reference-scaling: Don’t use FARTSSIE! Helmut 2017-12-01 11:42
- Reference-scaling: USE PowerTOST Astea 2017-12-01 14:16
- Reference-scaling: USE PowerTOST cakhatri 2017-12-04 06:00
- Reference-scaling: USE PowerTOST Helmut 2017-12-04 15:07
- Reference-scaling: USE PowerTOST cakhatri 2017-12-05 05:33
- Reference-scaling: USE PowerTOST Helmut 2017-12-04 15:07
- Use PowerTOST d_labes 2017-12-06 09:52
- Use PowerTOST, not Endrényi L, Tóthfalusi L tables mittyri 2017-12-07 16:03
- Precision in Endrényi L, Tóthfalusi L tables d_labes 2017-12-07 18:21
- Precision of PowerTOST mittyri 2017-12-08 22:56
- Precision of PowerTOST Helmut 2017-12-09 17:00
- Precision of PowerTOST mittyri 2017-12-09 21:05
- Precision of PowerTOST Astea 2017-12-10 00:10
- Precision of PowerTOST Helmut 2017-12-10 20:27
- Precision of PowerTOST Astea 2017-12-10 21:13
- Precision of PowerTOST Helmut 2017-12-10 20:27
- Precision of PowerTOST Astea 2017-12-10 00:10
- Precision of PowerTOST mittyri 2017-12-09 21:05
- Precision of PowerTOST Helmut 2017-12-09 17:00
- Precision of PowerTOST mittyri 2017-12-08 22:56
- Precision in Endrényi L, Tóthfalusi L tables d_labes 2017-12-07 18:21
- Use PowerTOST, not Endrényi L, Tóthfalusi L tables mittyri 2017-12-07 16:03
- Reference-scaling: USE PowerTOST cakhatri 2017-12-04 06:00
- Reference-scaling: USE PowerTOST Astea 2017-12-01 14:16
- Reference-scaling: Don’t use FARTSSIE! Helmut 2017-12-01 11:42
- Reference-scaling: Don’t use FARTSSIE! pjs 2018-02-09 13:08
- Reference-scaling: Don’t use FARTSSIE! Helmut 2018-02-09 20:15
- Reference-scaling: Don’t use FARTSSIE?Astea 2017-11-30 22:50
- Reference-scaling: Don’t use FARTSSIE! Helmut 2017-11-30 10:58