CVintra for Cmax > AUC, therefore use AUC for sample size? [Power / Sample Size]
Hi nobody,
Ah – the formerly pink, now black journal.
At least this is what the last sentence of the abstract says: “Hence, CV derived from AUC instead of Cmax should be used in sample-size calculation to achieve a sufficient, yet practical, test power. ”
Outright bizarre. Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share?
❝ Found this here:
❝ https://www.ncbi.nlm.nih.gov/pubmed/28257283
❝ […] if I understand this correctly, the authors say, CVintra for Cmax is generally higher than for AUC, therefore use AUC to estimate the sample size of your study.
Ah – the formerly pink, now black journal.

❝ Did I get this right?
At least this is what the last sentence of the abstract says: “Hence, CV derived from AUC instead of Cmax should be used in sample-size calculation to achieve a sufficient, yet practical, test power. ”
❝ Any thoughts on this approach?
Outright bizarre. Since the authors are of a CRO, maybe the love failed studies in order to repeat them? Do you have a copy to share?
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-07 17:14 [Power / Sample Size]
- CVintra for Cmax > AUC, therefore use AUC for sample size?Helmut 2017-08-07 18:40
- CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-07 19:52
- CVintra for Cmax > AUC, therefore use AUC for sample size? ElMaestro 2017-08-07 23:04
- CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-08 10:06
- CVintra for Cmax > AUC, therefore use AUC for sample size? jag009 2017-08-09 06:21
- CVintra for Cmax > AUC, therefore use AUC for sample size? nobody 2017-08-09 17:11
- CVintra for Cmax > AUC, therefore use AUC for sample size?Helmut 2017-08-07 18:40