TIE depends on CVwR (and n) [RSABE / ABEL]
Hi Yura,
What do you mean by “the index T-P”? For the EMA use the ‘Method A’ or ‘Method B’ as given in the Q&A-document. But instead of using the nominal α of 0.05 (i.e., the 100(1–2α) = 90% CI) apply the respective adjusted α. If the TIE would be inflated with α 0.05, the adjusted CI is always wider (i.e., conservative).
❝ Adjusted alpha is used to construct confidence intervals of the pharmacokinetic parameters for the index T-P?
What do you mean by “the index T-P”? For the EMA use the ‘Method A’ or ‘Method B’ as given in the Q&A-document. But instead of using the nominal α of 0.05 (i.e., the 100(1–2α) = 90% CI) apply the respective adjusted α. If the TIE would be inflated with α 0.05, the adjusted CI is always wider (i.e., conservative).
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- question of adjustment Yura 2017-04-25 15:14 [RSABE / ABEL]
- TIE depends on CVwR (and n) Helmut 2017-04-26 14:17
- TIE depends on CVwR (and n) Yura 2017-04-26 17:28
- TIE depends on CVwR (and n)Helmut 2017-04-26 18:00
- TIE depends on CVwR (and n) Yura 2017-04-26 18:55
- TIE depends on CVwR (and n) Yura 2017-04-28 11:13
- TIE = p(BE) at expanded limits Helmut 2017-04-28 19:16
- TIE = p(BE) at expanded limits Yura 2017-04-29 13:01
- TIE = p(BE) at expanded limits Helmut 2017-04-28 19:16
- TIE depends on CVwR (and n) Yura 2017-04-28 11:13
- TIE depends on CVwR (and n) Yura 2017-04-26 18:55
- TIE depends on CVwR (and n)Helmut 2017-04-26 18:00
- TIE depends on CVwR (and n) pjs 2018-02-28 14:33
- TIE depends on CVwR (and n) Helmut 2018-02-28 14:48
- TIE depends on CVwR (and n) pjs 2018-03-01 07:35
- Comparing methods for (S)ABE Helmut 2018-03-01 13:32
- Comparing methods for (S)ABE pjs 2018-03-05 14:50
- Simulating the Null Helmut 2018-03-05 17:40
- Comparing methods for (S)ABE pjs 2018-03-05 14:50
- Comparing methods for (S)ABE Helmut 2018-03-01 13:32
- TIE depends on CVwR (and n) pjs 2018-03-01 07:35
- Adjusting α Helmut 2018-03-07 16:21
- TIE depends on CVwR (and n) Helmut 2018-02-28 14:48
- TIE depends on CVwR (and n) Yura 2017-04-26 17:28
- TIE depends on CVwR (and n) Helmut 2017-04-26 14:17