Impact of minimum stage 2 sample size on the Type I Error [Two-Stage / GS Designs]
Hi Helmut,
I am sure you are right but I can't follow you, I mean can't readily understand what question you tried to answer.
So let me ask the forbidden question: "Can you reformulate?"
This is one thing I did not get. Does that logic also work when we simulate true GMR 0.8 or 1.25 for type I error? I find it hard to convince myself.
Somehow I guess regulators just wanted to say that inclusion of a single subject in stage 2 would not be ok. They are right and that is not rocket science.
I am sure you are right but I can't follow you, I mean can't readily understand what question you tried to answer.
So let me ask the forbidden question: "Can you reformulate?"
❝ Higher sample size ⇒ more degrees of freedom ⇒ narrower CI ⇒ higher probability to pass BE.
❝ In other words, the TIE will also increase and one would have to use a lower adjusted α.
This is one thing I did not get. Does that logic also work when we simulate true GMR 0.8 or 1.25 for type I error? I find it hard to convince myself.
Somehow I guess regulators just wanted to say that inclusion of a single subject in stage 2 would not be ok. They are right and that is not rocket science.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Impact of minimum stage 2 sample size on the Type I Error Helmut 2016-12-30 01:22 [Two-Stage / GS Designs]
- Impact of minimum stage 2 sample size on the Type I ErrorElMaestro 2016-12-30 12:12
- Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 14:01
- Impact of minimum stage 2 sample size on the TIE: example ElMaestro 2016-12-30 17:19
- Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 18:00
- Impact of minimum stage 2 sample size on the TIE: example ElMaestro 2016-12-30 18:50
- Bingo! Helmut 2016-12-30 19:00
- Impact of minimum stage 2 sample size on the TIE: example ElMaestro 2016-12-30 18:50
- Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 18:00
- Impact of minimum stage 2 sample size on the TIE: example ElMaestro 2016-12-30 17:19
- Impact of minimum stage 2 sample size on the TIE: example Helmut 2016-12-30 14:01
- Impact of minimum stage 2 sample size on the Type I ErrorElMaestro 2016-12-30 12:12