Bioequivalence and Bioavailability Forum

Pooling – example [Power / Sample Size]

posted by BE-proff – 2016-12-28 15:37 (3112 d 19:14 ago) – Posting: # 16898
Views: 11,313

Hi Helmut,

Do you provide calculation of CV upper limit in study protocols?
If yes, how do you explain regulators that you use upper limit instead of CV?

Maybe literature references?

Complete thread:

• Why do we need pooled CV? BE-proff 2016-08-24 08:48 [Power / Sample Size] 
  • Maximum CV might be misleading Helmut 2016-08-24 12:07
    • Maximum CV might be misleading BE-proff 2016-08-26 10:41
      • Pooling – example Helmut 2016-08-26 11:34
        • Pooling – exampleBE-proff 2016-12-28 14:37
          • in my protocols… Helmut 2016-12-29 12:27
  • Why do we need pooled CV? ElMaestro 2016-08-24 13:03
    • Yessir! Common sense! Helmut 2016-08-24 13:53
      • Common sense weighting before pooling mittyri 2016-08-24 15:13
    • Gut feeling is the answer! DavidManteigas 2016-08-25 11:09
      • The reasons not to pool Astea 2016-08-26 20:40
        • The reasons not to pool mittyri 2016-08-28 22:05
        • Know your drug/formulation! Helmut 2016-08-29 11:56