Sample Size II [Power / Sample Size]

posted by BE-proff – 2016-12-28 09:14 (2995 d 03:04 ago) – Posting: # 16892
Views: 10,258

Hi All,

Let's say I want to calculate sample size based on results of a previous study.

I have the following data:
n=20
CV=0.18 (for Cmax and AUC) ;-)
GMR1 = 0.97
GMR2=1.19

If to calculate size based on GMR1 I think it's better to use a script:

sampleN.TOST(CV=0.18, theta0=0.95)

+++++++++++ Equivalence test - TOST +++++++++++
            Sample size estimation
-----------------------------------------------
Study design:  2x2 crossover
log-transformed data (multiplicative model)

alpha = 0.05, target power = 0.8
BE margins = 0.8 ... 1.25
True ratio = 0.95,  CV = 0.18

Sample size (total)
 n     power
16   0.820357
:ok:

if to use GMR = 1.19 we see something terrible:

sampleN.TOST(CV=0.18, theta0=1.19)

+++++++++++ Equivalence test - TOST +++++++++++
            Sample size estimation
-----------------------------------------------
Study design:  2x2 crossover
log-transformed data (multiplicative model)

alpha = 0.05, target power = 0.8
BE margins = 0.8 ... 1.25
True ratio = 1.19,  CV = 0.18

Sample size (total)
 n     power
166   0.803570
- too many people...:no:

What to do in such situations?:confused:

Complete thread:

UA Flag
Activity
 Admin contact
23,406 posts in 4,919 threads, 1,748 registered users;
36 visitors (0 registered, 36 guests [including 11 identified bots]).
Forum time: 12:19 CET (Europe/Vienna)

The object of statistics is information.
The objective of statistics is the understanding of information
contained in data.    Irwin and Marylees Miller

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5