Significance of Group effect in Russia: why the type III is so 'important' [Two-Stage / GS Designs]
Dear Detlew,
Thank you very much, it clarifies a lot the R's model logic.
I would explain the current situation in Russia and why we are so interested in ANOVA type III.
Russian experts read your post with a letter from Barbara Davit.
Now in ALL cases when the Protocol does not state the splitting to the groups, they are requesting the analysis with a group term, if the study was conducted in groups (irrespective of the reasons and time).
As you know there is an algo in FDA guidance, if the Group term is significant, one cannot pool them and should proceed an analysis in one of the groups. (almost) End of Story.
Many protocols state that all effects should be fixed (according to EMA GL)!
So I tried to modify your code to get the significance level of group effect and I've found that I cannot reproduce ANOVA type III PHX results in R (using FDA approach and all-fixed-effects approach).

Thank you very much, it clarifies a lot the R's model logic.
I would explain the current situation in Russia and why we are so interested in ANOVA type III.
Russian experts read your post with a letter from Barbara Davit.
Now in ALL cases when the Protocol does not state the splitting to the groups, they are requesting the analysis with a group term, if the study was conducted in groups (irrespective of the reasons and time).
As you know there is an algo in FDA guidance, if the Group term is significant, one cannot pool them and should proceed an analysis in one of the groups. (almost) End of Story.
Many protocols state that all effects should be fixed (according to EMA GL)!
So I tried to modify your code to get the significance level of group effect and I've found that I cannot reproduce ANOVA type III PHX results in R (using FDA approach and all-fixed-effects approach).
❝ Better drink a good beer or a good glas of vine while contemplating about the meaning of life and that all.

—
Kind regards,
Mittyri
Kind regards,
Mittyri
Complete thread:
- Potvin C in the EU Helmut 2013-04-16 17:40 [Two-Stage / GS Designs]
- Potvin C in the EU ElMaestro 2013-04-17 02:31
- Potvin C in the EU Helmut 2013-04-17 12:23
- 2 Groups model FDA d_labes 2013-04-17 13:10
- 2 Groups model FDA Helmut 2013-04-17 16:37
- Group effects obsolete? d_labes 2013-04-18 09:55
- Group effects FDA/EMA Helmut 2013-04-19 14:34
- Group effects FDA/EMA mittyri 2014-08-21 15:34
- Group effects FDA/EMA ElMaestro 2014-08-21 17:31
- Group effects EMA mittyri 2014-10-01 11:25
- Group effects EMA ElMaestro 2014-10-01 11:31
- Group effects EMA Helmut 2014-10-01 13:24
- Group effects EMA VStus 2016-10-06 22:06
- Group effects EMA ElMaestro 2016-10-07 12:45
- Group effects EMA mittyri 2016-10-07 15:06
- Fixed effects model with Group term mittyri 2016-10-09 13:27
- Fixed effects model: changing the F, p values mittyri 2016-10-10 18:33
- Fixed effects model: changing the F, p values ElMaestro 2016-10-10 20:10
- Fixed effects model: changing the F, p values Helmut 2016-10-11 00:17
- Holy War of type III d_labes 2016-10-11 13:17
- Significance of Group effect in Russia: why the type III is so 'important'mittyri 2016-10-11 15:07
- Fixed effects model: changing the F, p values zizou 2016-10-11 01:06
- FDA group model in R mittyri 2016-10-11 13:43
- FDA group model in R ElMaestro 2016-10-12 01:07
- FDA group model in R VStus 2016-10-17 15:32
- FDA group model in R ElMaestro 2016-10-17 18:58
- FDA group model in R VStus 2016-10-20 13:57
- FDA group model in R ElMaestro 2016-10-17 18:58
- FDA group model in R mittyri 2016-10-11 13:43
- Fixed effects model: changing the F, p values ElMaestro 2016-10-10 20:10
- Fixed effects model with Group term VStus 2016-10-20 13:54
- Fixed effects model: changing the F, p values mittyri 2016-10-10 18:33
- Fixed effects model with Group term mittyri 2016-10-09 13:27
- Group effects EMA mittyri 2016-10-07 15:06
- Group effects EMA ElMaestro 2016-10-07 12:45
- Group effects EMA VStus 2016-10-06 22:06
- Group effects FDA/EMA zizou 2016-12-31 02:54
- Group effects FDA/EMA Helmut 2017-06-03 14:57
- Group effects EMA mittyri 2014-10-01 11:25
- Group effects FDA/EMA ElMaestro 2014-08-21 17:31
- Group effects FDA/EMA mittyri 2014-08-21 15:34
- Group effects FDA/EMA Helmut 2013-04-19 14:34
- 2 Groups model FDA hiren379 2013-08-22 14:32
- Homework Helmut 2013-08-23 11:53
- Group effects obsolete? d_labes 2013-04-18 09:55
- 2 Groups model FDA Helmut 2013-04-17 16:37
- 2 Groups model FDA d_labes 2013-04-17 13:10
- Potvin C in the EU Helmut 2013-04-17 12:23
- Potvin C in the EU ElMaestro 2013-04-17 02:31