Still SF [Two-Stage / GS Designs]
Hi Helmut,
Well, it's a proven solution (not by me!), just not quite legal in most of civilized countries ;)
After playing with data from other studies, I've made a suggestion that same recommendation is good single stage cross-over with 2 groups to keep the study safe or "conservative"... We can then demonstrate BE based on larger (first) group if requested by regulators.
Regards, VStus
❝ lucid words about SF and great ideas about hacking embeded Linux-machines.
Well, it's a proven solution (not by me!), just not quite legal in most of civilized countries ;)
❝ In a TSD we have some chances to demonstrate BE already in the first stage. Hence, my personal recommendation for n1 75-80% of the fixed sample’s n.
After playing with data from other studies, I've made a suggestion that same recommendation is good single stage cross-over with 2 groups to keep the study safe or "conservative"... We can then demonstrate BE based on larger (first) group if requested by regulators.
Regards, VStus
Complete thread:
- Replicated 4×2 and two-stage-design, in the same protocol Mauricio Sampaio 2015-04-06 08:37 [Two-Stage / GS Designs]
- Replicated 4×2 and two-stage-design, in the same protocol ElMaestro 2015-04-06 08:53
- Science fiction Helmut 2015-04-06 14:20
- Science fiction Dr_Dan 2016-03-04 10:33
- mindblowing ElMaestro 2016-10-11 07:44
- Natural constant as usual; not for reference-scaling Helmut 2016-10-11 09:50
- Consistency DavidManteigas 2016-10-11 11:25
- Natural constant as usual; not for reference-scaling Helmut 2016-10-11 09:50