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Hi DanielR,
(coloring by me)
If information includes the data listing then it is actually not difficult: Just extract either the period 1 data or the period 2 data, and do an evalution as though this was a parallel trial.
The principle in this approach has a troubled past as it was used to evaluate BE pivotally when there were significant sequence effects in 222BE trials, and it never caught on with regulators. That is fortunately not your dilemma here. For your purpose you can get a reasonably qualified idea of the total variabilities for T and R.
❝ I need to determine a sample size for a parallel design, but only have information from 2x2 designs.
(coloring by me)
If information includes the data listing then it is actually not difficult: Just extract either the period 1 data or the period 2 data, and do an evalution as though this was a parallel trial.
The principle in this approach has a troubled past as it was used to evaluate BE pivotally when there were significant sequence effects in 222BE trials, and it never caught on with regulators. That is fortunately not your dilemma here. For your purpose you can get a reasonably qualified idea of the total variabilities for T and R.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- sample size for a parallel design DanielR 2016-09-14 19:56 [Power / Sample Size]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- sample size for a parallel design mittyri 2016-09-14 21:49
- sample size for a parallel design DanielR 2016-09-15 00:08
- CI in 2X2 cannot tell you CVinter mittyri 2016-09-15 00:26
- CI in 2X2 cannot tell you CVinter DanielR 2016-09-15 17:45
- CI in 2X2 cannot tell you CVinter mittyri 2016-09-15 00:26
- sample size for a parallel design DanielR 2016-09-15 00:08
- "information"?ElMaestro 2016-09-19 12:44
- "information"? DanielR 2016-09-20 18:24
- sample size for a parallel design mittyri 2016-09-14 21:49
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