Post hoc Power [Power / Sample Size]

posted by ElMaestro  – Denmark, 2016-01-08 16:07 (3468 d 06:23 ago) – Posting: # 15805
Views: 12,947

Hi Jay,

❝ As per discussions previous posts, the post of power is not taken into much consideration.

❝ But when the post hoc power of AUCt and AUCinf is observed around 90-100% while the posthoc power of Cmax is less than 20%, then what would be the probable reason for the same.


First of all, I think you should mention how you calculate post-hoc power. Do you use GMR=0.95, GMR=1.0 or observed?
Anyways, low post-hoc power could be due to deviating GMR (for the case you use the observed GMR; this is likely a product failure) or it could be due to high variability, or both.

If you have a situation with deviating Cmax point estimate but OK AUCt point estimate, then you are facing a challenge.

Having said all, I must admit I am also in the camp of people who think post-hoc power is either rubbish or of very limited value.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,428 posts in 4,929 threads, 1,687 registered users;
86 visitors (0 registered, 86 guests [including 10 identified bots]).
Forum time: 23:30 CEST (Europe/Vienna)

No matter what side of the argument you are on,
you always find people on your side
that you wish were on the other.    Thomas Berger

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5