BLLOQ ≠ 0 with measured drug plasma conc. [🇷 for BE/BA]
Dear Helmut,
Thank you for your pointers of previous discussions. From the current practice of a BE/BA study, I still don't know, when we get a BQL for a conc. from analytical report, how to judge it's real zero (as illustrated by weidson's example/plot. subject# 16) or a BQL. My question is: has any analytical lab. had a chance to report real zero measured conc. in the analytical report?
Thank you for your pointers of previous discussions. From the current practice of a BE/BA study, I still don't know, when we get a BQL for a conc. from analytical report, how to judge it's real zero (as illustrated by weidson's example/plot. subject# 16) or a BQL. My question is: has any analytical lab. had a chance to report real zero measured conc. in the analytical report?

❝ ❝ ... why we will possibly have real zero conc. for the drug undergoing entero-hepatic recirculation. Are they just below LLOQ?
❝
❝ Yep, very likely they are. See these threads: #14584, #14925, #10603, #4182. I like Simon’s term “embedded BQLs”...
—
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
All the best,
-- Yung-jin Lee
bear v2.9.2:- created by Hsin-ya Lee & Yung-jin Lee
Kaohsiung, Taiwan https://www.pkpd168.com/bear
Download link (updated) -> here
Complete thread:
- bear v2.7.0 released yjlee168 2015-12-07 09:18 [🇷 for BE/BA]
- Suggestion ElMaestro 2015-12-07 10:12
- Suggestion yjlee168 2015-12-07 10:55
- Suggestion Helmut 2015-12-07 14:01
- Suggestion yjlee168 2015-12-07 18:51
- Suggestion Helmut 2015-12-07 14:01
- Suggestion yjlee168 2015-12-07 10:55
- bear v2.7.0 released Astea 2015-12-10 16:36
- if Clast is zero in bear yjlee168 2015-12-10 17:23
- if Clast is zero in bear Astea 2015-12-10 20:50
- if Clast is zero in bear yjlee168 2015-12-11 03:28
- if Clast is zero in bear Astea 2015-12-11 09:39
- if Clast is zero in bear yjlee168 2015-12-11 17:16
- if Clast is zero in bear Astea 2015-12-11 09:39
- if Clast is zero in bear yjlee168 2015-12-11 03:28
- bear v2.7.1 yjlee168 2015-12-15 10:21
- bear v2.7.1 Astea 2015-12-15 19:32
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
- BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
- BLLOQ ≠ 0 with measured drug plasma conc.yjlee168 2015-12-16 11:38
- BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
- BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
- BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
- zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
- BQL rules in bear mittyri 2016-02-01 22:16
- BQL rules in bear yjlee168 2016-02-02 10:59
- possible solutions? yjlee168 2016-02-02 21:30
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear yjlee168 2016-02-03 09:04
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
- Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
- error message in bear mahmoud-teaima 2016-02-09 04:55
- please check your dataset file yjlee168 2016-02-09 06:40
- please check your dataset file mahmoud-teaima 2016-02-09 15:00
- please check your dataset file yjlee168 2016-02-09 15:38
- please check your dataset file mahmoud-teaima 2016-02-09 15:00
- A possible R bug? yjlee168 2016-02-09 19:14
- Please avoid Full Quotes (“TOFU”)! Ohlbe 2016-02-09 00:51
- zero (0), missing (NA), or BLLOQ (0 or NA) in bear mahmoud-teaima 2016-02-08 21:28
- BQL rules in bear mittyri 2016-02-01 22:16
- zero-zero with AUC calculation in bear yjlee168 2016-01-30 19:00
- BLLOQ at first two time ponts, AUC calculation Astea 2016-01-30 17:11
- BLLOQ ∋ { 0, ≈0, BLLOQ{...} ∀ t > 0} yjlee168 2015-12-16 18:22
- BLLOQ ≠ 0 ∀ t > 0 Helmut 2015-12-16 12:40
- BLLOQ ≠ 0 with measured drug plasma conc.yjlee168 2015-12-16 11:38
- BLLOQ ≠ 0 with measured drug plasma conc. Helmut 2015-12-16 01:45
- BLLOQ ≠ 0 with measured drug plasma conc. yjlee168 2015-12-15 20:17
- bear v2.7.1 Astea 2015-12-15 19:32
- if Clast is zero in bear Astea 2015-12-10 20:50
- if Clast is zero in bear yjlee168 2015-12-10 17:23
- Suggestion ElMaestro 2015-12-07 10:12