An other one with 0.0304 [Two-Stage / GS Designs]
Dear Helmut,
I have another one:
Gould A. L.
"Group Sequential Extensions of a Standard Bioequivalence Testing Procedure"
Journal of Pharmacokinetics and Biopharmaceutics. Vol 23. No.1. 1995
Table I: critical value for n1=n2: 1.8753
Seems I have to change my personal preference stated in my post above.
That means on the other hand: Potvin und Konsorten were much more lucky then they should have been.
Thats great
.
❝ ... I think that Kieser/Rauch are correct in their lament about one- vs. two-sided Pocock’s limits. They argue for 0.0304 (which Jones/Kenward2 used in chapter 13 as well). Jennison/Turnbull give Cp (K=2, α=0.10) 1.875:
❝ rep(1-pnorm(1.875), 2)
❝ [1] 0.03039636 0.03039636
I have another one:
Gould A. L.
"Group Sequential Extensions of a Standard Bioequivalence Testing Procedure"
Journal of Pharmacokinetics and Biopharmaceutics. Vol 23. No.1. 1995
Table I: critical value for n1=n2: 1.8753
Seems I have to change my personal preference stated in my post above.
That means on the other hand: Potvin und Konsorten were much more lucky then they should have been.
Thats great

—
Regards,
Detlew
Regards,
Detlew
Complete thread:
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- Adaptive TSD vs. “classical” GSD Helmut 2015-12-03 03:11
- “classical” GSD alpha's d_labes 2015-12-03 09:47
- N sufficiently large‽ Helmut 2015-12-03 14:56
- An other one with 0.0304d_labes 2015-12-03 16:15
- An other one with 0.0304 Helmut 2015-12-03 16:26
- An other one with 0.0304d_labes 2015-12-03 16:15
- N sufficiently large‽ Helmut 2015-12-03 14:56
- Adaptive TSD vs. “classical” GSD Ben 2016-01-10 12:43
- “classical” GSD alpha's d_labes 2015-12-03 09:47
- Adaptive TSD vs. “classical” GSD Helmut 2015-12-03 03:11