Adaptive TSD vs. “classical” GSD [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2015-11-27 20:54 (3362 d 03:58 ago) – Posting: # 15681
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Hi Hötzi,

❝ Given all that: Why should one use a GSD instead of a TSD?


It is a great question, and I will not offer a definitive answer, but I will volunteer an opinion :-)

You can look at it this way: A GSD is a kind of TSD where you make assumptions about both the GMR and the CV (you use the anticipated ones, not the observed ones) when you transit from stage 1 to stage 2. That anticipated pair of CV+GMR is exactly the (or a) combo that naïvely doubles the sample size. Simple but extremely rigid.

Thereby the GSDs should be considered a relic from bygone ages when computers were not fast enough to allow simulations to achieve what Potvin et al. have done.

Pass or fail!
ElMaestro

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