Bioequivalence and Bioavailability Forum

EMA: adjusted α for scABEL (for no-nerds) [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2015-11-18 09:25 (3449 d 04:10 ago) – Posting: # 15647
Views: 8,546

Dear Helmut,

❝ ...

❝ R-code at the end for the nerds.

---

❝ library(PowerTOST)


❝ theta0   <- 0.90


❝ CV       <- c(0.3, 0.5)


❝ ...


# LL <- min(0.80, exp(-0.76*CV2se(CV[k])))          # EMA's ABEL
# UL <- 1/LL
# for those no-nerds who have forgotten the regulatory constant, the CVswitch 
# and the cap on widening like Helmut (because he doesn't go behind the cap)
limits <- scABEL(CV=CV[k],regulator="EMA")
LL <- limits[1]
UL <- limits[2]
# of course better to replace LL, UL in the code below with limits[1], limits[2]

❝ ...

BTW: What would you do all your times if PowerTOST wasn't build ?

Complete thread:

• EMA: adjusted α Helmut 2015-11-18 00:27 [RSABE / ABEL] 
  • EMA: adjusted α for scABEL (for no-nerds)d_labes 2015-11-18 08:25
    • In praise of Power­TOST Helmut 2015-11-18 16:01
  • iteratively adjusted α Helmut 2015-11-28 22:35
    • iteratively adjusted α - FDA d_labes 2015-12-08 09:35