Why not? [Power / Sample Size]

posted by d_labes  – Berlin, Germany, 2015-11-02 12:08 (3417 d 17:18 ago) – Posting: # 15598
Views: 7,355

Dear Jay,

❝ In pilot study results of a modified release molecule, the CV obtained for AUC5-t is 114% and the T/R is around 88%.

❝ Can one use CV for more than 100% i.e. 114% in above case for the calculation of pivotal sample size.


If you believe in that CV's, i.e. all was OK with the study conduct:
Why not?

There is not theoretical bound in the CV, beside it has to be > zero.

Regards,

Detlew

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