Power to the people [Two-Stage / GS Designs]
Hi John John
❝ Power at 20% (0.715)
❝ Power at 20% (0.846)
Whatever your power values stand for, they are not the correct ones for the Potvin TSD, method B.
You have to calculate the power at GMR=0.95, with alpha=0.0294 and CV from stage 1.
Here my results:
Both are below the targeted 80%. Thus your problem described above doesn't exists.
❝ Cmax CVintrasub (0.387) Ratio(%Ref) (81.439)
❝ Power at 20% (0.715)
❝
❝ AUC0-t CVintrasub (0.324) Ratio(%Ref) (110.662)
❝ Power at 20% (0.846)
Whatever your power values stand for, they are not the correct ones for the Potvin TSD, method B.
You have to calculate the power at GMR=0.95, with alpha=0.0294 and CV from stage 1.
Here my results:
# Cmax
power.TOST(alpha=0.0294, CV=0.387, n=36, theta0=0.95)
[1] 0.3783821
# AUC
power.TOST(alpha=0.0294, CV=0.324, n=36, theta0=0.95)
[1] 0.5946074
Both are below the targeted 80%. Thus your problem described above doesn't exists.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Sequential trial with B method of Potvin john john 2015-10-01 17:44 [Two-Stage / GS Designs]
- Sequential trial with B method of Potvin ElMaestro 2015-10-01 17:58
- Sequential trial with B method of Potvin Helmut 2015-10-01 18:13
- Sequential trial with B method of Potvin john john 2015-10-07 11:26
- Power to the peopled_labes 2015-10-07 13:49
- Power to the people john john 2015-10-07 14:54
- Software? Ethics beyond statistics… Helmut 2015-10-07 16:06
- Subtraction of a df ElMaestro 2015-10-07 21:22
- df = df-1 d_labes 2015-10-08 08:10
- Subtraction of a df ElMaestro 2015-10-07 21:22
- Software? Ethics beyond statistics… Helmut 2015-10-07 16:06
- Power to the people john john 2015-10-07 14:54
- Potvin B: α 0.0294 in both stages Helmut 2015-10-08 15:27
- Potvin B: α 0.0294 in both stages john john 2015-10-23 12:04
- Power to the peopled_labes 2015-10-07 13:49
- Sequential trial with B method of Potvin john john 2015-10-07 11:26