Different power of AUC vs. Cmax at stage I - continuation rules [Two-Stage / GS Designs]
Hi ElMaestro,
Many thanks for your prompt response.
May I ask why it is not so commonly used?
What about a case in which AUC doesn't meet the BE criteria at stage I, but its power is >80% due to the low ISCV, while Cmax power is <80%? Could we still continue to stage II?
Thanks again,
Nisha
Many thanks for your prompt response.
❝ good to hear the 2-stage approaches have not drawn their last breath.
May I ask why it is not so commonly used?
❝ You would still be analysing AUCt and Cmax at stage II if one such is conducted, even if AUCt has been shown BE at stage I.
What about a case in which AUC doesn't meet the BE criteria at stage I, but its power is >80% due to the low ISCV, while Cmax power is <80%? Could we still continue to stage II?
Thanks again,
Nisha
Complete thread:
- Different power of AUC vs. Cmax at stage I - continuation rules Nisha 2015-09-17 13:28 [Two-Stage / GS Designs]
- Different power of AUC vs. Cmax at stage I - continuation rules ElMaestro 2015-09-17 13:56
- Different power of AUC vs. Cmax at stage I - continuation rulesNisha 2015-09-17 20:27
- AUC vs. Cmax ElMaestro 2015-09-17 21:53
- Assumption Helmut 2015-09-18 00:15
- Different power of AUC vs. Cmax at stage I - continuation rulesNisha 2015-09-17 20:27
- Different power of AUC vs. Cmax at stage I - continuation rules ElMaestro 2015-09-17 13:56