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RegisterAlmighty oracle's mysterious saying [RSABE / ABEL]
Dear Helmut!
Full ACK
As every Pythia's saying: Mysterious!
Nowhere in the scABEL method there is an term utilizing the 'uncertainty' of the variability of the reference.
Contrary to the FDA RSABE which has such a term.
That's the reason why both 3-period designs (TRR|RTR|RRT or TRT|RTR) require similar numbers of subjects.
And deeming 12 subjects as sufficient to 'control' that 'uncertainty' is at least strange (politely spoken):
From no widening up to cap on widening!
But the net effect is of course pleasing
.
❝ Parturient montes, nascetur ridiculus mus. Horace (Ars poetica, Ep.II.3, 139)
Full ACK
As every Pythia's saying: Mysterious!
Nowhere in the scABEL method there is an term utilizing the 'uncertainty' of the variability of the reference.
Contrary to the FDA RSABE which has such a term.
That's the reason why both 3-period designs (TRR|RTR|RRT or TRT|RTR) require similar numbers of subjects.
And deeming 12 subjects as sufficient to 'control' that 'uncertainty' is at least strange (politely spoken):
library(PowerTOST)
CVCL(CV=0.3, df=12-2, "2-sided")
lower CL upper CL
0.2072921 0.5513299 From no widening up to cap on widening!
But the net effect is of course pleasing
.—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- 3 period full replicate Dr_Dan 2015-06-24 13:55 [RSABE / ABEL]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- 3 period full replicate ElMaestro 2015-06-24 14:11
- 3 period full replicate Helmut 2015-06-24 14:29
- 3 period full replicate d_labes 2015-06-24 14:38
- 3 period full replicate Dr_Dan 2015-06-24 16:43
- 3 period full replicate Helmut 2015-06-24 18:00
- 3 period full replicate ElMaestro 2015-06-24 18:11
- 3 period full replicate Helmut 2015-06-24 18:25
- 3 period full replicate d_labes 2015-06-25 08:52
- 3 period full replicate ElMaestro 2015-06-25 10:37
- 3 period full replicate d_labes 2015-06-25 08:52
- 3 period full replicate Helmut 2015-06-24 18:25
- 3 period full replicate ElMaestro 2015-06-24 18:11
- CVs (borderline OT) Helmut 2015-06-26 13:51
- CVs (R, T) from pooled CV d_labes 2015-07-02 09:09
- Answering an unasked question Helmut 2015-07-02 13:03
- Answer to an unasked answer d_labes 2015-07-02 14:21
- Bloody typo! Helmut 2015-07-02 14:33
- Answer to an unasked answer d_labes 2015-07-02 14:21
- Answering an unasked question Helmut 2015-07-02 13:03
- CVs (borderline OT) zizou 2015-07-05 19:20
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
- Degrees of freedom 3-period full replicate ElMaestro 2015-07-06 11:59
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 13:53
- Degrees of freedom 3-period full replicate zizou 2015-07-06 17:25
- Degrees of freedom 3-period full replicate ElMaestro 2015-07-06 11:59
- Degrees of freedom 3-period full replicate d_labes 2015-07-06 11:10
- CVs (R, T) from pooled CV d_labes 2015-07-02 09:09
- 3 period full replicate Helmut 2015-06-24 18:00
- 3 period full replicate Dr_Dan 2015-06-24 16:43
- The almighty oracle has spoken! Helmut 2015-07-23 23:54
- Almighty oracle's mysterious sayingd_labes 2015-07-24 08:23
Ing. Helmut Schütz