Hypotheses in non-inferiority trials [Power / Sample Size]
I can't seem to be able to respond to Mittyri (the system logs me out when I press the respond button), so I'll respond to Mittyri here via responding to myself.
Thank you, Mittyri. I've printed it out and browsed it. Will grab another coffee and re-read it with my full attention.
In my research, I keep running into statements like this: Type II error has heightened importance in non-inferiority trials and must be managed. If sample size is inadequate, then a non-inferiority trial may lead to a false claim of a drug being non-inferior to a comparator when in fact it is worse.
These types of statements seems to undermine the argument on post hoc power—they seem to claim that post hoc power is meaningful. Am I misinterpreting these kind of statements? Are they valid?
Thank you,
Outlaw Torn
Edit: Strange – I moved your post in the database. [Helmut]
Thank you, Mittyri. I've printed it out and browsed it. Will grab another coffee and re-read it with my full attention.
In my research, I keep running into statements like this: Type II error has heightened importance in non-inferiority trials and must be managed. If sample size is inadequate, then a non-inferiority trial may lead to a false claim of a drug being non-inferior to a comparator when in fact it is worse.
These types of statements seems to undermine the argument on post hoc power—they seem to claim that post hoc power is meaningful. Am I misinterpreting these kind of statements? Are they valid?
Thank you,
Outlaw Torn
Edit: Strange – I moved your post in the database. [Helmut]
Complete thread:
- The power of post hoc power The Outlaw Torn 2015-05-13 12:49 [Power / Sample Size]
- The power of post hoc power ElMaestro 2015-05-13 17:53
- Ad hoc power d_labes 2015-05-13 20:18
- Ad hoc power The Outlaw Torn 2015-05-14 11:38
- Ad hoc power The Outlaw Torn 2015-06-15 11:20
- Hypotheses in non-inferiority trials mittyri 2015-06-16 21:52
- Hypotheses in non-inferiority trialsThe Outlaw Torn 2015-06-17 11:35
- Hypotheses in non-inferiority trials d_labes 2015-06-18 10:17
- Hypotheses in non-inferiority trials The Outlaw Torn 2015-06-22 10:23
- Hypotheses in non-inferiority trials arjunroy 2015-06-29 08:24
- Hypotheses in non-inferiority trials The Outlaw Torn 2015-06-22 10:23
- Hypotheses in non-inferiority trials d_labes 2015-06-18 10:17
- Hypotheses in non-inferiority trialsThe Outlaw Torn 2015-06-17 11:35
- Hypotheses in non-inferiority trials mittyri 2015-06-16 21:52
- Ad hoc power The Outlaw Torn 2015-06-15 11:20
- Ad hoc power The Outlaw Torn 2015-05-14 11:38
- Ad hoc power d_labes 2015-05-13 20:18
- The power of post hoc power ElMaestro 2015-05-13 17:53