SAS code for 3-period, partial-replicated cross­over study [RSABE / ABEL]

posted by ElMaestro  – Denmark, 2015-06-15 15:46 (3534 d 01:35 ago) – Posting: # 14960
Views: 6,952

Hi MGR,

❝ One of my sponsor asked to do a Partial replicate study, in which there are two tests and one reference. What will be the possible sequences used in the study?


It would be permutations of T1T2RR.
It does not sound right to me, intuition and such, but it is definitely possible. 4 periods.

If you insist on 3 periods, I wonder if you could do Perm(RRT1) and Perm(RRT2). Three periods, 6 sequences.... rubbish? Some subjects would not be exposed to both Tests I guess. Naw, this sounds too weird too for my taste buds.

Pass or fail!
ElMaestro

Complete thread:

UA Flag
Activity
 Admin contact
23,381 posts in 4,914 threads, 1,663 registered users;
25 visitors (0 registered, 25 guests [including 7 identified bots]).
Forum time: 16:22 CET (Europe/Vienna)

Science is built up with facts, as a house is with stones.
But a collection of facts is no more a science
than a heap of stones is a house.    Henri Poincaré

The Bioequivalence and Bioavailability Forum is hosted by
BEBAC Ing. Helmut Schütz
HTML5