Old beliefs die hard [Two-Stage / GS Designs]

posted by ElMaestro  – Denmark, 2015-05-29 20:57 (3541 d 13:21 ago) – Posting: # 14887
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Hi Hötzi,

that was another good post. To state it a little differently:
We are trying to build confidence in the point estimate, this is the whole point of the (any) BE study. At a time when we have very little confidence in it we will not be rewarded from trying to make use of it. That is in a nutshell why the two-stage approaches do not work when we try to use the PE from stage 1.

I think we need it published, or some other way to get the message across. Telling companies that it doesn't work, well... doesn't work.
"Mr. Birdsong is not helping the project forward." vs "Mr. Birdsong is offering an opportunity to avoid a sad and brainless waste of money." The interpretation is commonly the former, rarely the latter :-D

Pass or fail!
ElMaestro

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