Bioequivalence and Bioavailability Forum

Old beliefs die hard [Two-Stage / GS Designs]

posted by Helmut  – Vienna, Austria, 2015-05-29 15:27 (3549 d 20:04 ago) – Posting: # 14884
Views: 20,184

Hi nobody,

❝ Is that a new trend, to setup trial designs without checking the appropriate statistics to evaluate the results (see also 2-stage scaled BE trials)? Just asking...

No, it isn’t.
As I wrote above »I know some companies routinely applying this “method”«… At least one of them is a very (very!) big player. During two in-house trainings they didn’t believe me (“We never [sic] faced any problems in our sub­mis­sions!”).

Old beliefs die hard
even when demonstrably false.   E.O. Wilson

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

• Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29 [Two-Stage / GS Designs] 
  • Maybe; but watch the TIE! Helmut 2015-05-28 15:04
    • Advantages d_labes 2015-06-05 09:35
      • Advantages ElMaestro 2015-06-05 10:07
        • Advantages – performance measure d_labes 2015-06-05 11:21
          • Advantages – performance measure Helmut 2015-06-05 13:29
            • Advantages – performance measure d_labes 2015-06-05 21:27
              • Advantages – performance measure Helmut 2015-06-05 23:29
                • Histogram wonder d_labes 2015-06-06 12:58
                  • Histogram charlatanry Helmut 2015-06-09 13:43
                    • Histogram beauty d_labes 2015-06-09 14:55
                      • Histogram beast Helmut 2015-06-09 15:24
  • Does unequal alpha distribution make sense? Dr_Dan 2015-05-29 08:33
    • Does unequal alpha distribution make sense? ElMaestro 2015-05-29 09:31
      • Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
        • Old beliefs die hardHelmut 2015-05-29 13:27
          • Old beliefs die hard nobody 2015-05-29 13:41
            • Old beliefs die hard Helmut 2015-05-29 18:08
              • Old beliefs die hard ElMaestro 2015-05-29 18:57
                • Old beliefs die hard nobody 2015-05-29 20:06
                • ♩ ♪♫♬`·.¸¸.·´`·.¸¸. Helmut 2015-06-02 01:52
                  • TSD only an option in ex­ceptional cases Dr_Dan 2015-06-02 08:00
                    • TSD only an option in ex­ceptional cases nobody 2015-06-02 09:23
                      • OT Helmut 2015-06-02 12:07
                        • OT nobody 2015-06-02 12:41
  • Banana splits Helmut 2015-06-02 00:48