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RegisterDoes unequal alpha distribution make sense? [Two-Stage / GS Designs]
Hi Dr_Dan,
It is generally a 1-2*alpha confidence interval so in this case the coverage is 91.74%.
So far no method has been published where the observed GMR can be used and where power is not suffering and/or sample size going through the roof. And equally troubling noone has published the proof that using the observed GMR doesn't work. I know at least three different groups of researchers (or two groups and one individual) have been looking at it. I think it is a matter of journals not wishing to publish negative results. Lack of these publications have already caused a few projects to fail as far as I know.
❝ Stage I: 0.001 leading to 99.8% CI
❝ Stage II: 0.0413 leading to 9?.?% CI ???
It is generally a 1-2*alpha confidence interval so in this case the coverage is 91.74%.
❝ For the sample size calculation for the second stage you use the GMR 0.95 or the GMR as calculated from stage I results?
So far no method has been published where the observed GMR can be used and where power is not suffering and/or sample size going through the roof. And equally troubling noone has published the proof that using the observed GMR doesn't work. I know at least three different groups of researchers (or two groups and one individual) have been looking at it. I think it is a matter of journals not wishing to publish negative results. Lack of these publications have already caused a few projects to fail as far as I know.
—
Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Does unequal alpha distribution make sense? Dr_Dan 2015-05-19 08:29 [Two-Stage / GS Designs]
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
- Advantages d_labes 2015-06-05 09:35
- Advantages ElMaestro 2015-06-05 10:07
- Advantages – performance measure d_labes 2015-06-05 11:21
- Advantages – performance measure Helmut 2015-06-05 13:29
- Advantages – performance measure d_labes 2015-06-05 21:27
- Advantages – performance measure Helmut 2015-06-05 23:29
- Histogram wonder d_labes 2015-06-06 12:58
- Histogram charlatanry Helmut 2015-06-09 13:43
- Histogram beauty d_labes 2015-06-09 14:55
- Histogram beast Helmut 2015-06-09 15:24
- Histogram beauty d_labes 2015-06-09 14:55
- Histogram charlatanry Helmut 2015-06-09 13:43
- Histogram wonder d_labes 2015-06-06 12:58
- Advantages – performance measure Helmut 2015-06-05 23:29
- Advantages – performance measure d_labes 2015-06-05 21:27
- Advantages – performance measure Helmut 2015-06-05 13:29
- Advantages – performance measure d_labes 2015-06-05 11:21
- Advantages ElMaestro 2015-06-05 10:07
- Advantages d_labes 2015-06-05 09:35
- Does unequal alpha distribution make sense? Dr_Dan 2015-05-29 08:33
- Does unequal alpha distribution make sense?ElMaestro 2015-05-29 09:31
- Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
- Old beliefs die hard Helmut 2015-05-29 13:27
- Old beliefs die hard nobody 2015-05-29 13:41
- Old beliefs die hard Helmut 2015-05-29 18:08
- Old beliefs die hard ElMaestro 2015-05-29 18:57
- Old beliefs die hard nobody 2015-05-29 20:06
- ♩ ♪♫♬`·.¸¸.·´`·.¸¸. Helmut 2015-06-02 01:52
- TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
- TSD only an option in exceptional cases nobody 2015-06-02 09:23
- TSD only an option in exceptional cases Dr_Dan 2015-06-02 08:00
- Old beliefs die hard ElMaestro 2015-05-29 18:57
- Old beliefs die hard Helmut 2015-05-29 18:08
- Old beliefs die hard nobody 2015-05-29 13:41
- Old beliefs die hard Helmut 2015-05-29 13:27
- Does unequal alpha distribution make sense? nobody 2015-05-29 12:56
- Does unequal alpha distribution make sense?ElMaestro 2015-05-29 09:31
- Banana splits Helmut 2015-06-02 00:48
- Maybe; but watch the TIE! Helmut 2015-05-28 15:04
Ing. Helmut Schütz